Cystic fibrosis is a metabolic, hereditary and lethal disease. It is caused by the presence of mutations in the genes responsible for the transport of salt and water in the cells.
This unwanted disease produces thick secretions instead of thin secretions. There is no known cure, but there are attempts to slow down the progression of the disease. The symptoms depend on the organ that is being affected.
The damage to the lungs is the result of dense mucosa that blocks the airways, causing breathing difficulties, chronic cough, easy bacterial growth and pneumonia. In later stages, changes in the composition of the tissue cause asthma, the expulsion of blood when coughing, high pressure, cardiorespiratory complications and later death.
The gastrointestinal tract also has thicker secretions, especially from the pancreas, the part of the body in charge of producing the digestive juices that help break down food. These thick secretions plug the pancreatic ducts, blocking the digestive enzymes within the intestines and hindering the absorption of nutrients (malabsorption).
Thus, patients often suffer from osteoporosis, diarrhea or poor growth. In addition, the accumulation of excretory fluids within the pancreas causes recurrent stomach pain, swelling, diabetes and life-threatening consequences. On the other hand, in the liver there are also solidified secretions, which congest the bile ducts, causing cirrhosis and later can cause death.
In newborns, the first bowel movement can be dangerous due to the presence of meconium, a viscous material composed of cells, amniotic fluid, bile, water and mucosa. This can result in a bowel obstruction that may require surgical intervention.
Cystic fibrosis and fertility problems
In addition, cystic fibrosis can cause infertility problems in both women and men. In women, the mucosa in the uterus and fallopian tubes is more viscous, which hinders fecundation by sperm. On the other hand, malnutrition interrupts ovulation and menstruation.
In men, sperm do not enter the ejaculate. The main reason is the congenital absence of the vas deferens (the ejaculatory ducts of the penis that connect with the testicles), but also by other mechanisms, involving an abnormal shape, poor motility or no sperm. About 98% of male patients with cystic fibrosis are infertile.
There is no known cure for cystic fibrosis
Cystic fibrosis has no cure. However, efforts are being made to alleviate the symptoms of those affected and to slow down the progression of the disease.
The average life expectancy has reached 37.5 years, although many patients live much longer today. Frequently, improvement in access to health care and new medications have led to an improvement in prognosis. In 1962, the average age of survival was only 10 years. Now it is very likely that affected children born after 2000 may exceed 50 years.
What do the studies say about medical cannabis and cystic fibrosis?
A study conducted by the Ariel University Center of Samaria in Israel concluded that an imbalance in fatty acids is associated with cystic fibrosis. In this sense, and since the endocannabinoids are derived from fatty acids, the endocannabinoid system is also altered. Apparently, this failure in the body is the determining factor that produces infertility.
In addition, a low stimulation of cannabinoid receptors with tetrahydrocannabinol (THC) in childhood and adolescence appears to normalize the endocannabinoid system and prevents infertility in adult male mice.
The research presents positive and promising conclusions in animals, but not in humans. In particular, the concept related to pharmaceutical products and environmental agents can be a bad predictor of human reactions. Therefore, more clinical trials are needed to confirm whether such therapy will produce similar benefits, if not the same, in people.
Finally, other cannabinoids should be investigated for treat cystic fibrosis. For example, Cannabidiol (CBD), a component without psychoactive effects of the cannabis plant. Its anti-inflammatory effects could prevent inflammation in the lungs or digestive tract.
Did you like this post? Make an assessment. This post has been made based on existing research until the date of publication of the article. Due to the increase of studies around medical cannabis, the information exposed may vary over time and we will inform in subsequent writings.
Here’s what you need to know before seeing your local medical dispensary:You will need a physician’s recommendation, medical cannabis certificate, and/or whatever appropriate documentation is needed by your condition. Ordinarily, you need to be 18 or older to qualify for a medical authorization, but exceptions may be made in some conditions for minors with especially debilitating conditions. You will often enroll with a medicinal dispensary. This is to keep your medical cannabis recommendation or certification on file for regulatory and legal purposes. There will be a waiting room. This is to control the flow of patients and product, but a simple dividing wall also gives patients solitude and direct one-on-one contact using a budtender to candidly discuss medical issues. This procedure can help budtenders and patients track effective medicine in addition to have a living listing of producers and products for future reference and follow up. Medicinal dispensaries usually permit you to smell and analyze the buds before buy. This might vary from state-to-state.
DOES AN APPLICANT NEED MUNICIPAL APPROVAL BEFORE RECEIVING A RETAIL CANNABIS LICENSE? Yes, municipal approval is required prior to the AGLC will issue a retail cannabis license. Applicants must get in touch with their planned municipality to find out requirements concerning municipal retail cannabis legislation, zoning requirements, land-use restrictions, and location requirements regarding how near a retail store can be to a provincial health care facility, college, or parcel of land designated as a college book.
Keep non-medical cannabis legal Adults that are 19 years or older are in a position to:Have up to 30 g of authorized dried cannabis or the equivalent on their own person. Share up to 30 g of legal cannabis along with other adults in Canada. Buy cannabis goods from a Yukon Liquor Corporation licensed retailer. Grow up to four crops per family. It’s illegal to provide non invasive cannabis to anyone under the age of 19 and also for anybody below the age of 19 to have any quantity of non-medical cannabis in Yukon.It is illegal and dangerous to drive while under the influence of cannabis or other intoxicants.