Cannabinoids to relieve acute pancreatitis – Posting Medical Cannabis Store Quebec Canada

Herb Approach

The pancreas is an organ located behind the stomach and facing the first and second lumbar vertebrae. It is formed by lobes, small ducts come from each lobe and are emptied into a larger duct, this pancreatic duct and the common bile duct come together and enter the duodenum (intestine). The pancreas produces internal and external enzymes (proteins), which are necessary for digestion. Acute pancreatitis (AP) is a disease that consists of the sudden inflammation of the pancreas.

Causes of pancreatitis

The main causes of pancreatitis are the presence of gallstones trapped in the pancreatic ducts or inflammation of the gallbladder. Either of these two causes causes an obstruction of the common duct, which prevents digestive enzymes from penetrating the intestines.

The disease can be very dangerous. The most common symptoms include abdominal pain Superior radiation radiating to the back, difficulty breathing without pulmonary cause, nausea and persistent vomiting, which rarely improve with medication. You can also find high levels of blood sugar or urine, as well as an increase in the cells of the immune system. The treatment does not include anything that can be ingested. Only rehydration, analgesics and nutritional support intravenously. Surgical care may be indicated in some casesone.

Medicinal cannabis and acute pancreatitis

The inflammatory response in the pancreas is an important factor in the development of the disease. The anti-inflammatory potential of cannabis it has been a topic of interest since the endocannabinoid system was discovered in mammals. However, there is also clinical evidence that cannabis could induce acute pancreatitis.

Benefits of cannabinoids in the relief of acute pancreatitis

In 2013, a preclinical study showed the anti-inflammatory role of cannabidiol in mice with acute pancreatitis. Cannabidiol (CBD) is a non-psychotropic bioactive component of cannabis with therapeutic properties.

The results showed that treatment with CBD decreased TNF-alpha and IL-6. Both are proinflammatory proteins secreted mainly by T cells, macrophages, neutrophils and endothelial cells; all these cells express endocannabinoid receptors in their structures. The presence of these receptors allows cannabinoids such as CBD to act on them and, therefore, relieve pain and control acute pancreatitistwo.

In 2017, a clinical study was conducted to analyze the severity and results of acute alcoholic pancreatitis in cannabis users. Patients were studied during the period from 2006 to 2015. The urine drug screening test for THC was performed on patients.

Tetrahydrocannabinol (THC) is the psychotropic component of cannabis. In terms of results, the researchers observed that among patients with positive THC, her acute pancreatitis was much less severe and much less painful than that of patients who had not used cannabis. Therefore, patients with positive THC were less likely to be admitted to intensive care units.

On the other hand, the study found that cannabidiol increases the levels of IL-10, an anti-inflammatory protein, while THC, did not make any changes. Whatever the type of cannabinoid, the timing and route of consumption, as well as the consumption of alcohol, were not measured in the study. Therefore, more studies are needed to define the effects of medical cannabinoids in patients with acute pancreatitis.3.

Possible risks

In 2017, a research group conducted a systematic review of the literature on acute cannabis-induced pancreatitis. The results showed that cannabis is a possible risk factor for the development of acute pancreatitis, especially in patients younger than 35 years. Recurrent PA (57.7%) in patients, related to cannabis use, and (50%) of patients with respect to other episodes of acute pancreatitis after cannabis stoppage were also reported. However, the lack of cannabis consumption parameters in this study affected the ability to be exempted from the dose in the population. The mechanism remains unknown, but in animal models, the activation of CB1 receptors by anandamide, an endogenous natural activating ligand, caused a worsening of the severity of acute pancreatitis at high doses.[4].

Today, data on cannabinoids and acute pancreatitis are conflicting, researchers are calling for further studies to better understand the molecular mechanism involved in this painful and dangerous condition.

Did you like this post? Make an assessment. This post has been made based on existing research until the date of publication of the article. Due to the increase of studies around medical cannabis, the information exposed may vary over time and we will inform in subsequent writings.

[1] Sommermeyer, L. (1935). Acute Pancreatitis. The American Journal of Nursing, 35 (12), 1157.doi: 10.2307 / 3412015

[2] Li, K., Feng, J., Li, Y., Yuece, B., Lin, X., Yu, L., Storr, M. (2013). Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice. Pancreas, 42 (1), 123-129.doi: 10.1097 / mpa.0b013e318259f6f0

[3] Goyal H, Guerreso K, Smith B, Harper K, Patel S, Patel A, et al. Severity and outcomes of acute alcoholic pancreatitis in cannabis users. Transl Gastroenterol Hepatol 2017; 2:60

[4] Barkin, J.A., Nemeth, Z., Saluja, A.K., & Barkin, J.S. (2017). Cannabis-Induced Acute Pancreatitis. Pancreas, 46 (8), 1035-1038.doi: 10.1097 / mpa.0000000000000873

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Cannabinoids to relieve acute pancreatitis

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Cannabinoids to relieve acute pancreatitis

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Cannabinoids may help fight acute pancreatitis. The anti-inflammatory potential of cannabis has been an interesting topic to treat this disease.

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Teo

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Kalapa Clinic

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