Cannabinoids to treat Refractory Obsessive Compulsive Disorder – Delivery Marihuana Store Edmonton Canada

Herb Approach

The Obsessive Compulsive Disorder (TOC) is a mental illness caused by anxiety or anguish, and characterized by the presence of persistent thoughts, or rather, obsessions. These constant thoughts are suppressed with new thoughts or actions, also known as compulsions. Compulsions are defined as acts provoked in response to the obsession that pretend to avoid anxiety or anguish[1].

The word 'refractory' applies to diseases that do not react to treatment. About 60% of patients with OCD do not respond to the first treatment. The alternatives in these cases could be an increase in the dose or change the medication completely. In this sense, a new test reported on patients who are resistant to OCD treatment and who could respond better to an increase in doses of medications combined with medicinal cannabis.

Improve refractory obsessive-compulsive disorder

In 2008, a group of researchers published an article in the American Journal of Psychiatry. In this article, the researchers highlighted the experiences of two patients with refractory obsessive-compulsive disorder, a man and a woman, after the administration of synthetic THC.

The woman was prescribed an antidepressant, a selective serotonin reuptake inhibitor, and psychological therapy to manage her OCD and depression for 8 months, but it did not work. When switching to a new antidepressant, tricyclic antidepressant, it resulted in a partial response after 12 weeks of treatment. Interestingly, the patient reported that when she smoked cannabis, her symptoms were relieved. Based on this personal experience, it was decided to supplement their current treatment with synthetic THC. In just 10 days, his symptoms of obsessive-compulsive disorder decreased, and his severity disease score improved by 50%.

On the other hand, the man was prescribed antipsychotics, either in monotherapy or in combination with an antidepressant, selective inhibitor of serotonin reception, without success either. The partial response to their psychotic and refractory symptoms of obsessive-compulsive disorder was only possible with an atypical antipsychotic medication (clozapine) in combination with an antidepressant (selective inhibitor of serotonin reuptake). Subsequently, the patient tried to switch to another antidepressant (tricyclic antidepressant) and additional electroconvulsive therapy, but did not improve. In your case, after the addition of Synthetic THC Ongoing medication, symptoms of refractory obsessive-compulsive disorder were reduced by 2 weeks, and their disease score improved by 35%. No side effects were reported in these patients.

Based on these two cases, the researchers hypothesized that cannabinoids are definitely useful in the treatment of the symptoms of people with refractory OCD[2].

In 2010, a clinical study was published later in the Journal Behavioral Pharmacology, describing the observation of the effects of cannabidiol (CBD) in rodents, subject to an animal model proposed to reflect compulsive behavior. In this study, the researchers found that CBD, a component of cannabis that has anxiolytic effects, in both animals and humans, could significantly reduce the symptoms associated with animal behavior for a significant duration, since the effects of CBD were still present after 7 days of administration. A similar decrease was found using benzodiazepine diazepam and paroxetine, a selective inhibitor of serotonin reuptake. However, the effect of diazepam was no longer present after 7 days. Then, the results suggest a potential role of cannabinoids in the cannabinoid system to control compulsive behavior[3].

In general, these studies demonstrated a therapeutic potential of cannabinoids to reduce obsessive compulsive disorders. However, new studies are needed to definitively validate its usefulness or not.

Did you like this post? Make an assessment. This post has been made based on existing research until the date of publication of the article. Due to the increase of studies around medical cannabis, the information exposed may vary over time and we will inform in subsequent writings.

[1] Hirschtritt, M.E., Bloch, M.H., & Mathews, C.A. (2017). Obsessive-Compulsive Disorder. JAMA, 317 (13), 1358. doi: 10.1001 / jama.2017.2200

[2] Schindler, F., Anghelescu, I., Regen, F., & Jockers-Scherubl, m. (2008). Improvement in Refractory Obsessive Compulsive Disorder With Dronabinol. American Journal of Psychiatry, 165 (4), 536-537.doi: 10.1176 / appi.ajp.2007.07061016

[3] Casarotto PC, Gomes FV, ​​Resstel LB, Guimaraes FS. Cannabidiol inhibitory effect on marble-burying behavior: involvement of CB1 receptors. Behav Pharmacol 2010; 21: 353-358.


Cannabinoids to treat Refractory Obsessive Compulsive Disorder


Cannabinoids to treat Refractory Obsessive Compulsive Disorder


Can cannabinoids be useful for refractory obsessive-compulsive disorder (OCD)? Some studies confirm it, but more research is needed.



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