Malaria is an infectious disease caused by Anopheles mosquitoes. The insect bite introduces the parasite (Plasmodium) into a person's blood. Fighting malaria is complicated. There are five species of Plasmodium that can cause this disease, but Plasmodium vivax Y Plasmodium falciparum They are the most dangerous. This disease is present mainly in sub-Saharan Africa, Latin America or Southeast Asia.
Between 10 and 15 days after infection, various symptoms appear: fever, headache, vomiting and cold. If left untreated within 24 hours, malaria can be aggravated and lead to death. In children, severe anemia, respiratory distress in relation to metabolic acidosis or cerebral malaria often develops. In adults, multiorgan failure, immunity and asymptomatic infections are common symptoms in people with malaria.
In 2017, 219 million cases of malaria were estimated worldwide.
Can cannabinoids help treat and fight malaria?
The marijuana plant produces several compounds, including the main cannabinoids: Tetrahydrocannabinol (THC) and Cannabidiol (CBD). In the last ten years, cannabinoids have emerged as modulators of the central nervous system and the immune system, acting through the endocannabinoid system.
In this neuroprotective scenario and together with antimalarial drugs, medicinal cannabis would be an interesting strategy to combat malaria and improve the neurological outcome in humans. In addition, the potential of cannabis to reduce the pathogenic manifestation of malaria disease is of special interest to the scientific community.
Recent evidence and effectiveness
Neuromalaria or cerebral malaria is the most common complication of Plasmodium infection. It can lead to irreversible neurological and behavioral deficits, being responsible for more than 80% of lethal cases.
A 2015 study examined cerebral malaria in an animal model and the effect of cannabiniol on its cognitive function. In this work, the female mice were infected and treated with CBD for 7 days, and on the fifth day after infection (at the peak of the disease), the rodents received a conventional antimalarial treatment. The rodents were subjected to memory tests and behaviors similar to anxiety, at the peak or after the complete elimination of the disease. Cerebral inflammatory factors (TNF-alpha / IL-6) and nerve growth proteins (brain-derived neurotrophic factor, BDNF) were measured.
The results showed that rodents treated only with antimalarial drugs, had memory deficits and exhibited an increase in behaviors similar to anxiety, while mice treated with CBD did not. Further, the mice treated with CBD had a neuroprotective effect, which involved a regulation of brain cytokines and an increase in BDNF levels, which could be useful in preventing neurological symptoms. However, more studies are needed to determine the mechanism involved.
In Nigeria, it is claimed that the intake of marijuana from dried leaves, seeds and twigs protects against malaria.
In 2018, an article evaluated the effects of cannabis use in a host infected with malaria. Thirty mice were inoculated with Plasmodium. The formulation of the cannabis diet was prepared based on the standard diet of mice and in weighted percentages of dry cannabis. The formulation of the cannabis diet was 40%, 20%, 10% and 1%.
The animals were separated into groups, which included a group with only conventional antimalarial treatment and different groups of animals fed with a cannabis diet formulation (40%, 20%, 10% and 1%). The animals were fed, either or as needed for 14 days. The presence of the parasite in blood and the survival rates were evaluated. The results showed a significant suppression of the parasites on day 4 in the group of animals fed with a 40% sativa diet formulation, as well as in the animals treated with the antimalarial drug.
In addition, the ingestion of C. sativa, in the correct dose, increases the survival of the infected animals, although it was not as effective as the antiparasitic drug. In conclusion, C. sativa showed a slight protection against the activity of the malaria parasite in vivo, it is not curative, but it can mediate an effect of tolerance to the disease during the infection of malaria. However, more research is needed to identify which components of cannabis may have mediated the benefits described in this study..
These studies have demonstrated the multiple properties of cannabinoids as an alternative antimalarial therapy; in any case, new scientific studies must be carried out to discover more medicinal cannabis potential to fight malaria.
Did you like this post? Make an assessment. This post has been made based on existing research until the date of publication of the article. Due to the increase of studies around medical cannabis, the information exposed may vary over time and we will inform in subsequent writings.
 Campos, A.C., Brant, F., Miranda, A.S., Machado, F.S., & Teixeira, A.L. (2015). Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria. Neuroscience, 289, 166-180.doi: 10.1016 / j.neuroscience.2014.12.051
 Akinola, O. et alt. (2018). Oral Ingestion of Cannabis sativa: Risks, Benefits, and Effects on Malaria-Infected Hosts. Cannabis and Cannabinoid Research, 3 (1), 219-227. doi: 10.1089 / can.2018.0043
Here’s what you need to know before visiting your local medical dispensary:You may require a doctor’s recommendation, medical cannabis certificate, or whatever proper documentation is needed by your condition. Typically, you need to be 18 or older to be eligible for a medical authorization, but exceptions may be made in some conditions for minors with particularly debilitating problems. You will often register with a medicinal dispensary. This is to keep your medical cannabis recommendation or certificate on file for regulatory and legal purposes. There will be a waiting room. This is to control the flow of patients and product, but a straightforward dividing wall gives patients solitude and direct one-on-one contact with a budtender to candidly discuss medical problems. This procedure can help budtenders and patients monitor effective medication in addition to possess a living record of producers and goods for future reference and follow up. Medicinal dispensaries usually allow you to smell and analyze the buds prior to buy. This may differ from state-to-state.
DOES AN APPLICANT NEED MUNICIPAL APPROVAL BEFORE RECEIVING A RETAIL CANNABIS LICENSE? Yes, municipal approval is necessary prior to the AGLC will subject a retail cannabis license. Applicants must get in contact with their planned municipality to find out requirements concerning municipal retail cannabis laws, zoning requirements, land-use limitations, and location requirements concerning how near a retail store can be into a provincial medical care facility, school, or parcel of property designated as a school reserve.
Keep non-medical cannabis legal Adults that are 19 decades or older are able to:Have up to 30 g of authorized dried cannabis or the equivalent on their own person. Share up to 30 g of legal cannabis along with other adults in Canada. Buy cannabis products from a Yukon Liquor Corporation licensed merchant. Grow up to four plants per family. It’s illegal to provide non invasive cannabis to anyone below the age of 19 and also for anyone below the age of 19 to possess any quantity of anti inflammatory cannabis in Yukon.It is dangerous and illegal to drive while under the influence of cannabis or other intoxicants.