CBD to fight malaria? – Delivery Cannabis Dispensary Brampton Canada

Herb Approach

Malaria is an infectious disease caused by Anopheles mosquitoes. The insect bite introduces the parasite (Plasmodium) into a person's blood. Fighting malaria is complicated. There are five species of Plasmodium that can cause this disease, but Plasmodium vivax Y Plasmodium falciparum They are the most dangerous. This disease is present mainly in sub-Saharan Africa, Latin America or Southeast Asia.

Between 10 and 15 days after infection, various symptoms appear: fever, headache, vomiting and cold. If left untreated within 24 hours, malaria can be aggravated and lead to death. In children, severe anemia, respiratory distress in relation to metabolic acidosis or cerebral malaria often develops. In adults, multiorgan failure, immunity and asymptomatic infections are common symptoms in people with malaria.

In 2017, 219 million cases of malaria were estimated worldwide.

Can cannabinoids help treat and fight malaria?

The marijuana plant produces several compounds, including the main cannabinoids: Tetrahydrocannabinol (THC) and Cannabidiol (CBD). In the last ten years, cannabinoids have emerged as modulators of the central nervous system and the immune system, acting through the endocannabinoid system.

In this neuroprotective scenario and together with antimalarial drugs, medicinal cannabis would be an interesting strategy to combat malaria and improve the neurological outcome in humans. In addition, the potential of cannabis to reduce the pathogenic manifestation of malaria disease is of special interest to the scientific community.

Recent evidence and effectiveness

Neuromalaria or cerebral malaria is the most common complication of Plasmodium infection. It can lead to irreversible neurological and behavioral deficits, being responsible for more than 80% of lethal cases.

A 2015 study examined cerebral malaria in an animal model and the effect of cannabiniol on its cognitive function. In this work, the female mice were infected and treated with CBD for 7 days, and on the fifth day after infection (at the peak of the disease), the rodents received a conventional antimalarial treatment. The rodents were subjected to memory tests and behaviors similar to anxiety, at the peak or after the complete elimination of the disease. Cerebral inflammatory factors (TNF-alpha / IL-6) and nerve growth proteins (brain-derived neurotrophic factor, BDNF) were measured.

The results showed that rodents treated only with antimalarial drugs, had memory deficits and exhibited an increase in behaviors similar to anxiety, while mice treated with CBD did not. Further, the mice treated with CBD had a neuroprotective effect, which involved a regulation of brain cytokines and an increase in BDNF levels, which could be useful in preventing neurological symptoms. However, more studies are needed to determine the mechanism involved[1].

In Nigeria, it is claimed that the intake of marijuana from dried leaves, seeds and twigs protects against malaria.

In 2018, an article evaluated the effects of cannabis use in a host infected with malaria. Thirty mice were inoculated with Plasmodium. The formulation of the cannabis diet was prepared based on the standard diet of mice and in weighted percentages of dry cannabis. The formulation of the cannabis diet was 40%, 20%, 10% and 1%.

The animals were separated into groups, which included a group with only conventional antimalarial treatment and different groups of animals fed with a cannabis diet formulation (40%, 20%, 10% and 1%). The animals were fed, either or as needed for 14 days. The presence of the parasite in blood and the survival rates were evaluated. The results showed a significant suppression of the parasites on day 4 in the group of animals fed with a 40% sativa diet formulation, as well as in the animals treated with the antimalarial drug.

In addition, the ingestion of C. sativa, in the correct dose, increases the survival of the infected animals, although it was not as effective as the antiparasitic drug. In conclusion, C. sativa showed a slight protection against the activity of the malaria parasite in vivo, it is not curative, but it can mediate an effect of tolerance to the disease during the infection of malaria. However, more research is needed to identify which components of cannabis may have mediated the benefits described in this study.[2].

These studies have demonstrated the multiple properties of cannabinoids as an alternative antimalarial therapy; in any case, new scientific studies must be carried out to discover more medicinal cannabis potential to fight malaria.

Did you like this post? Make an assessment. This post has been made based on existing research until the date of publication of the article. Due to the increase of studies around medical cannabis, the information exposed may vary over time and we will inform in subsequent writings.

[1] Campos, A.C., Brant, F., Miranda, A.S., Machado, F.S., & Teixeira, A.L. (2015). Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria. Neuroscience, 289, 166-180.doi: 10.1016 / j.neuroscience.2014.12.051

[2] Akinola, O. et alt. (2018). Oral Ingestion of Cannabis sativa: Risks, Benefits, and Effects on Malaria-Infected Hosts. Cannabis and Cannabinoid Research, 3 (1), 219-227. doi: 10.1089 / can.2018.0043


CBD to fight malaria?


CBD to fight malaria?


Some recent studies have investigated how medicinal cannabis can help fight malaria


Tim Meiboon

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