According to the National Institute of Mental Health, the term psychosis is used to describe conditions that affect the mind. During an episode of psychosis, a person's thoughts may have difficulty understanding what is real and what is not.
Psychosis: symptoms, causes and treatment with medicinal cannabis
The symptoms include illusions, hallucinations, a speech without sense, social isolation, lack of motivation, difficulty to function with normality in general, as well as depression, anxiety and sleep problems.
Psychosis can have different causes such as schizophrenia, bipolar disorder, sleep deprivation, certain medication and drugs, such as alcohol or cannabis (psychosis induced by cannabis).
While chronic cannabis use and the early onset of psychosis have been linked in some patients, recent studies indicated that two of the main cannabinoids found in the cannabis plant -the cannabidiol (CBD) and tetrahydrocannabinol (THC) – have opposite reactions in the human brain with respect to psychopathology. While THC can induce symptoms in healthy individuals caused by cannabis use, CBD could reduce them. In addition, when CBD is co-administered with THC, it was able to reduce the psychogenic action of THC.
Research on medicinal cannabis and psychosis
In 2018, a clinical investigation in humans was carried out to study the therapeutic potential of CBD. The experts found that a single dose of CBD administered orally could normalize dysfunction in certain regions of the brain (temporal lobe, mesencephalon and striatum), which are implicated in the processes that cause the disease, but the mechanisms remain unclear.
Preclinical models propose that overactivity in the temporal lobe region leads to subcortical dopamine dysfunction through projections to the mesencephalon and striatum. On the other hand, contemporary studies with neuroimaging confirm that a later onset of psychosis is related to a increase in the functions of dopamine in the striatum and mesencephalon, and alterations in the structure of the temporal lobe. The temporal lobe is a critical area for new learning, while the mesencephalon and striatum also play a role in coding and updating information in memory.
Antipsychotic drugs act by antagonizing central Dopamine D receptorstwo, but the therapeutic response is poor in up to a third of patients. CBD has been reported as useful in patients who have not responded to this type of medication (for example: haloperidol). The endocannabinoid system is involved in the regulation of cannabinoids within the human body.
Another article published in the American Journal of Psychiatry showed that CBD has beneficial effects as adjunctive treatment for schizophrenia. After six weeks of treatment with CBD (twice a day) along with the existing antipsychotic medication, the results showed lower levels of positive psychotic symptoms, good tolerance and rates of adverse events similar to those of the placebo group.
As the mechanisms of action of the CBD do not seem to depend on dopamine receptor antagonists, a number of actions have been proposed, including inhibition of Adenosine collection, inhibition of fatty acid amide hydrolase, agonism of TRPV1 and 5-HT receptors1A and partial agonism by the dopamine D2 receptor.
The conclusion of this multicentre randomized controlled trial suggests that CBD may present a new class of treatment for this disorder. However, more research about medicinal cannabis treatments for large-scale psychosis is necessary.
Did you like this post? Make an assessment. This post has been made based on existing research until the date of publication of the article. Due to the increase of studies around medical cannabis, the information exposed may vary over time and we will inform in subsequent writings.
 RAISE Questions and Answers. NIMH Retrieved 23 January 2018
 Large M, Sharma S, Compton MT, Slade T, Nielssen O. Cannabis use and earlier onset of psychosis: a systematic meta-analysis. Arch Gen Psychiatry 2011; 68: 555-61.
 Bhattacharyya S, Morrison PD, Fusar-Poli P, Martin-Santos R, Borgwardt S, Winton-Brown T et al. Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology 2010; 35: 764-774.
 Bhattacharyya, S, Wilson, R, Appia-Kusi, E, et al. (2018) Effect of cannabidiol on medial temporal, midbrain, and striatal dysfunction in people at clinical high risk of psychosis: a randomized clinical trial. JAMA Psychiatry, 75: 1107-17.
 McGuire, P. et al. Cannabidiol (CBD) as an adjunctive therapy in schizophrenia: a multicenter randomized controlled trial. Am. J. Psychiatry 175, 225-231 (2017).
Here’s what you want to know before seeing your local medical dispensary:You may need a doctor’s recommendation, medical cannabis certificate, or whatever proper documentation is required by your state. Typically, you must be 18 or older to be eligible for a medical authorization, but exceptions could be made in some states for minors with particularly debilitating problems. You will often register with a medicinal dispensary. This is to keep your medical cannabis recommendation or certificate on file for legal and regulatory purposes. There will be a waiting space. This is to control the flow of patients and product, but a simple dividing wall gives patients privacy and direct one-on-one contact with a budtender to candidly discuss medical problems. Many times, but not necessarily, your purchases will be monitored by medical dispensaries. This procedure can assist budtenders and patients monitor effective medication in addition to have a living listing of manufacturers and goods for future reference and follow up. Medicinal dispensaries usually permit you to smell and examine the buds before purchase. This might differ from state-to-state.
DOES AN APPLICANT NEED MUNICIPAL APPROVAL BEFORE RECEIVING A RETAIL CANNABIS LICENSE? Yes, municipal approval is required before the AGLC will issue a retail cannabis license. Applicants should get in contact with their intended municipality to learn requirements regarding municipal retail cannabis laws, zoning requirements, land-use limitations, and place requirements concerning how close a retail shop can be into a provincial medical care facility, school, or parcel of land designated as a school reserve.
Keep non-medical cannabis legal Adults that are 19 years or older are able to:Possess up to 30 gram of authorized dried cannabis or the equivalent on their own person. Share up to 30 gram of legal cannabis along with other adults in Canada. Purchase cannabis goods from a Yukon Liquor Corporation licensed retailer. Grow up to four plants per household. It is illegal to present non invasive cannabis to anyone below the age of 19 and also for anybody below the age of 19 to have any quantity of anti inflammatory cannabis in Yukon.It is illegal and dangerous to drive while under the influence of cannabis or other intoxicants.