Today, medical cannabis It is rapidly gaining the interest of many people with different diseases. But does cannabis also help with breast cancer?
Breast cancer It is one of the most common causes of death among women. Early diagnosis and the development of new therapies have significantly improved the prognosis, but many patients have congenital or acquired resistance to current therapies. Therefore, new therapeutic approaches are of great importance for the treatment of the disease.
Cannabinoids may trigger reactions against breast cancer
Extensive research has shown that cannabis could be useful in breast cancer because cannabinoids, the active substances found in cannabis plants, can trigger antitumor reactions in several animal cancer models.
The majority of the studies were carried out with the main psychoactive component of the plant, Δ9-tetrahydrocannabinol (THC). However, cannabis plants still produce countless other compounds with their own therapeutic potentials. A combined use of all the components of the cannabis plant induces a synergistic reaction, the so-called "entourage effect", which offers a greater medical effect, compared to the use of a single isolated cannabinoid.
In addition, it has been observed that the use of cannabinoids in conjunction with current breast cancer therapy drugs has provided a better antiproliferative effect in laboratory cells, compared to pure THC administrations. There have been no interactions due to the combination of these treatments. In summary, the results suggest that standardized cannabis preparations could be used instead of pure cannabinoids for the treatment of breast cancer.
The CBD in reducing chemoresistance
Cannabidiol (CBD), a non-psychoactive phytocannabinoid produced by cannabis plants, has demonstrated properties antioxidants, anti-inflammatory and anti-proliferative.
According to a recent study by the Metropolitan University of London, CBD was probably able to inhibit the release of exosomes and microvesicles (EMV) in adenocarcinoma cells (a type of breast cancer). The EMV are lipid structures enclosed in bilayer released by the cells and involved in the communication through the transfer of proteins and genetic material. EMV release is also associated with cancer, where a high release is associated with chemoresistance and the active transfer of cancer genes, among other things.
New studies show that EMV inhibitors they can make cancer cells more sensitive to chemotherapeutic agents and limit cancer growth. CBD significantly reduced the release of exosomes from cancer cells and significantly inhibited the release of microvesicles.
In addition, evidence suggests that changes in mitochondrial function, including modulation of STAT3 (a protein that increases the expression of certain genes), and prohibition (PHB – a mitochondrial protein that modulates the expression of certain genes) may be associated with the inhibition of EMV release. This leads to the conclusion that CBD can be used to make cancer cells more susceptible to chemotherapy..
CBDA prevents the spread of breast cancer cells
In cannabis plants CBD first appears in its acid form, known as the acronym CBDA. Cannabidiolic acid cannabinoid (CBDA) It is becoming increasingly the focus of many investigations. Some studies have shown that CBDA provides inhibition of cycloociconase-2 (COX-2) activities. COX-2 has been detected in 40% of invasive human breast cancers and their functions have been linked to the migration of tumor cells.
In a recent study, researchers identified a possible mechanism whereby the CBDA repeals COX-2 expression by decreasing the complex by decreasing c-fos, a component of the activator protein-1 dimer complex (AP-1). Ap-1 is a transcriptional factor (a macroprotein) that controls COX-2 gene expression in the nucleus of cells. This leads to the conclusion that CBDA, as an anti-migration agent, It can be very useful in aggressive human breast cancer cells by decreasing the activity of COX-2.
Different studies have reported on the evidence that medical cannabis could support current breast cancer treatment, but in order to make an accurate statement as to how useful it is and how exactly it should be used, it is necessary to carry carry out more research and studies in humans.
Did you like this post? Make an assessment. This post has been made based on existing research until the date of publication of the article. Due to the increase in studies on medical cannabis, the information presented may vary over time and we will inform in subsequent writings.
 Blasco-Benito, S., et alt. (2018). Appraising the “entourage effect”: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer. Biochemical Pharmacology doi: 10.1016 / j.bcp. 2018.06.025
 Kosgodage, U. S., et alt. Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. Frontiers in Pharmacology, 9.doi: 10.3389 / fphar. 2018.00889
 Takeda, S., et alt. (2016). Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness. Journal of Natural Medicines, 71 (1), 286-291. doi: 10.1007 / s11418-016-1030-0
Here’s what you need to know before seeing your regional medical dispensary:You may require a doctor’s recommendation, medical cannabis certificate, and/or whatever proper documentation is needed by your state. Ordinarily, you must be 18 or older to qualify for a medical authorization, but exceptions may be made in some states for minors with especially debilitating problems. You will usually register with a medicinal dispensary. This is to maintain your medical cannabis recommendation or certificate on file for regulatory and legal purposes. There will be a waiting space. This is to control the flow of product and patients, but a simple dividing wall gives patients privacy and direct one-on-one contact using a budtender to discuss medical problems. Many times, but not always, your purchases will be tracked by medical dispensaries. This process can help budtenders and patients track effective medicine as well as have a living listing of producers and products for future reference and follow-up. Medicinal dispensaries usually allow you to smell and examine the buds before purchase. This may vary from state-to-state.
Yes, municipal approval is required prior to the AGLC will issue a retail cannabis license. Applicants must get in touch with their planned municipality to learn requirements regarding municipal retail cannabis laws, zoning requirements, land-use limitations, and location requirements regarding how near a retail shop is into a provincial health care centre, school, or parcel of property designated as a school reserve.
Keep non-medical cannabis legal Adults that are 19 years or older are able to:Have up to 30 gram of legal dried cannabis or the equivalent in their own person. Share up to 30 g of legal cannabis along with other adults in Canada. Buy cannabis products from a Yukon Liquor Corporation licensed merchant. Grow up to four crops per household. It is illegal to provide non-medical cannabis to anyone under the age of 19 and also for anybody under the age of 19 to have any amount of non-medical cannabis in Yukon.It is dangerous and illegal to drive while under the influence of cannabis or other intoxicants.